6-Nitrobenzo[b]thiophene1,1-dioxide

Name	Stattic
Synonyms	Stattic AKOS 1001 1,1-DIOXO-6-NITROBENZO(B)THIOPHENE 6-Nitrobenzo[b]thiophene1,1-dioxide 6-Nitro-1-benzothiophene 1,1-dioxide 6-NITRO-1H-1LAMBDA6-BENZO[B]THIOPHENE-1,1-DIONE 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
CAS	19983-44-9

Molecular Formula	C8H5NO4S
Molar Mass	211.19
Density	1.621±0.06 g/cm3(Predicted)
Melting Point	187-188 °C
Boling Point	461.1±45.0 °C(Predicted)
Solubility	DMSO: >20mg/mL
Appearance	powder
Color	white to beige
Storage Condition	Sealed in dry,2-8°C
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
In vitro study	Stattic inhibits the binding of gp130 receptor-derived phosphorylated tyrosine-containing peptides to the STAT3 SH2 domain in a strong temperature-dependent manner. Stattic has only a very weak effect on the binding of tyrosine phosphorylated peptides to the SH2 domain of tyrosine kinase Lck. Stattic does not inhibit the dimerization of the other two dimeric transcription factors (c-Myc/Max and Jun/Jun). Stattic inhibits the binding of fluorescein-labeled phosphorylated peptides to the SH2 domains of STAT1 and STAT5b. The concentration of Stattic is 10 μm, which selectively inhibits the binding of DNA to STAT3 dimer. Stattic inhibits phosphorylation of STAT3 at Tyr705, while it has little inhibitory effect on phosphorylation of STAT1 at Tyr701(HepG2 cells) or phosphorylation of JAK1, JAK2, and c-Src(MDA-MB-231 and MDA-MB-235S cells). Stattic increases the rate of apoptosis in a stat3-dependent breast cancer cell line.

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3
Hazard Note	Irritant

Last Update：2024-01-02 23:10:35

biological activity	Stattic is the first non-peptide small molecule, which effectively inhibits STAT3 activation and nuclear translocation, the IC50 was 5.1 μm, which was highly selective for stat1. Stattic is the first non-peptide small molecule inhibitor of STAT3, which effectively inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μm, and its selectivity for STAT3 is much higher than stat1. Stattic can induce apoptosis.
features	Stattic is the first small non-peptide molecule that inhibits the function of the STAT3 SH2 domain, regardless of the STAT3 phosphorylation status in vitro.
Target	Value
STAT3 (Cell-free assay)	5.1 μM
Use	a potent inhibitor of STAT3 activation and dimerization. Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Stattic has been used as a tool for probing the upstream activation of this factor, significantly expressed in many cancer cell lines and interruption of this pathway in breast cancer cell lines lead to an increased apoptotic rate in these cells. Stat3 Inhibitor V, Stattic is an inhibitor of Stat3.

Last Update：2024-04-09 20:49:11

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CAS: 19983-44-9
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Spot supply

Product Name: Stattic Visit Supplier Webpage Request for quotation
CAS: 19983-44-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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6-Nitrobenzo[b]thiophene1,1-dioxide

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